Aerobic Propagation using sophisticated ABEC propagator train
The pilot plant includes a full CIP/SIP propagation skid. Three 50L vessels can be run in series or parallel with a 500L propagator. All are equipped with heating/cooling temperature, airflow, pressure, dissolved oxygen and pH controls as well as off-gas measurement via mass spectrometry. Data is collected into the pilot plant DCS historian.
Aerobic Fermentors with a broad operating range
The three 26,000L (7000 gallon) aerobic fermentors in the ICM pilot plant have internal cooling coils and external jackets to provide maximum cooling rates. The vessels have a 1.2:1 height to diameter ratio and sparge rings capable of delivering 600 SCFM of air. Off-gas monitoring via mass spectrometry is also available along with the full suite of normal process control features including dissolved oxygen and agitation. Data is collected into the pilot plant DCS historian.
Axenic operations keep your monoculture pure
ICM employs skilled team members that execute advanced protocols and testing to monitor the process, ensuring axenic aerobic fermentations to support your scale-up requirements. The ICM team has experience aerobically growing various fungi, bacteria and algae.
Multiple operation modes available
The aerobic fermentors can be run in full batch mode, to define scaling factors from the lab, but also fed-batch and continuous modes using the continuous sterilizer or dedicated media vessels to maximize productivity. The system collects all relevant mass balance and operations data into the DCS historian.
Agitation was designed to handle moderately viscous media at higher oxygen transfer rates.
Scale-up from cleanroom vial to 26,000L
Bench Scale Bioreactors (1-14L)
ABEC Propagation (50-500L)
Aerobic Fermentation (26,000L)
Full axenic/sterile operations
Batch, fed-batch and continuous operation modes
Mass spectroscopy analysis of off-gas
Elevated viscosity agitation